Mechanism of Action

Fomicyt® has a unique mode of action – working at an earlier stage of cell wall synthesis than any other antibiotic 1,2

Fomicyt - Mode Of Action
  • Fomicyt® exerts a bactericidal effect on proliferating pathogens by preventing the enzymatic synthesis of the bacterial cell wall 2
  • It inhibits the first stage of intracellular bacterial cell wall synthesis by blocking peptidoglycan synthesis 2
  • It acts as a competitive inhibitor of the enzyme UDP-N-acetylglucosamine-3-0 enolpyruvyl transferase (PEP-Transferase; Mur A) 2
  • Fomicyt® therefore breaks down the bacteria’s defence at an earlier stage than other antibiotics, which confers speed of action 2
  • Fomicyt® has an additive or synergistic effect with a range of other antibiotics,2,3 and is also an effective combination partner in the treatment of biofilm infections 4

  1. Gobernado M. Rev Esp Quimioterap 2003;16(1):15-40.
  2. Fosfomycin as Partner Drug for Systemic Infection Management. A Systematic Review of Its Synergistic Properties from In Vitro and In Vivo Studies.
  3. Falagas ME et al. Clin Microbiol Rev 2016;29:321–347.
  4. Emerging Concepts for the Treatment of Biofilm-Associated Bone and Joint Infections with IV Fosfomycin: A Literature Review.